COVID VACCINE: PREGNANCY AND PLACENTA | Is the COVID Vaccine Safe in Pregnancy?

Dr. Natalie Crawford, board certified OBGYN and REI, discussed the COVID vaccine in pregnancy and placental changes. Does the COVID vaccine cause sterilization? Does the COVID vaccine attack the placenta? Does the COVID vaccine cause an increase in miscarriage or stillbirth? Is the COVID vaccine safe if breastfeeding? Is the COVID vaccine safe in pregnancy?

*up to date as of May 17, 2021

This is educational content and not medical advice. Please ask your doctor and specific questions that may pertain to your medical care.

Study reviewed:
Shanes ED, Otero S, Mithal LB, Mupanomunda CA, Miller ES, Goldstein JA. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccination in Pregnancy: Measures of Immunity and Placental Histopathology. Obstet Gynecol. 2021 May 11.

THE SKIMM: https://www.theskimm.com/well/covid-19-vaccine-period-pregnancy-3Cwag5n554gxCEo03P4sbQ

Other studies discussed:
Mithal LB, Otero S, Shanes ED, Goldstein JA, Miller ES. Cord
blood antibodies following maternal COVID-19 vaccination
during pregnancy. Am J Obstet Gynecol 2021.

Gray KJ, et al. COVID-19 vaccine response in pregnant and lactating women: a cohort study. Am J Obstet Gynecol. 2021 Mar 24:S0002-9378(21)00187-3.

Perl SH, Uzan-Yulzari A, Klainer H, et al. SARS-CoV-2–Specific Antibodies in Breast Milk After COVID-19 Vaccination of Breastfeeding Women. JAMA. 2021;325(19):2013–2014.

Schwartz DA, Baldewijns M, Benachi A, Bugatti M, Collins
RRJ, De Luca D, et al. Chronic histiocytic intervillositis with
trophoblast necrosis is a risk factor associated with placental
infection from coronavirus disease 2019 (COVID-19) and intrauterine
maternal-fetal severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) transmission in live-born and stillborn
infants. Arch Pathol Lab Med 2020;145:517–28. doi: 10.
5858/arpa.2020-0771-SA

U, Lu-Culligan A, et al. SARS-CoV-2 infection of the placenta. J Clin Invest. 2020 Sep 1;130(9):4947-4953. doi: 10.1172/JCI139569. PMID: 32573498; PMCID: PMC7456249.
Shimabukuro TT, et al. Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons. NEJM. April 21, 2021. 
Villar J, Ariff S, Gunier RB, et al. Maternal and Neonatal Morbidity and Mortality Among Pregnant Women With and Without COVID-19 Infection: The INTERCOVID Multinational Cohort Study. JAMA Pediatr. Published online April 22, 2021. doi:10.1001/jamapediatrics.2021.1050

Perl SH, Uzan-Yulzari A, Klainer H, et al. SARS-CoV-2–Specific Antibodies in Breast Milk After COVID-19 Vaccination of Breastfeeding Women. JAMA. 2021;325(19):2013–2014. doi:10.1001/jama.2021.5782
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Dr. Natalie Crawford, MD is a double board certified OBGYN and REI, and co-founder of Fora Fertility, a boutique fertility practice in Austin, Texas.

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