Which Fertility Drugs Cause Multiples?

Increasing numbers of multiple births have been linked to fertility treatments such as in vitro fertilization (IVF). This process is known to implant more than one embryo. Fertility drugs are considered the most common cause of multiples, according to a recent study. It was found that 36% of twin births and 77% of triplet births were a direct result of fertility treatments.

Letrozole and Metformin

Letrozole and Metformin are a prescription drug that are often prescribed to women with type 2 diabetes. These medications are also used to treat polycystic ovary syndrome (PCOS). Both conditions are caused by increased blood sugar levels, and the treatments are designed to decrease blood sugar levels by increasing the sensitivity of the body to the hormone insulin. However, there are risks associated with these drugs and the medications are not right for every woman.

Letrozole is an FDA-approved medication used to induce ovulation. It has significantly higher live birth rates than clomiphene, so it is often recommended for women with PCOS. Metformin can help women with PCOS prevent miscarriage during pregnancy, and has also been proven to reduce the incidence of diabetes during pregnancy.


Although multiples are rare, a woman who has anovulatory cycles should seek treatment with clomiphene to improve her chances of conceiving a healthy baby. The chances of having multiples increase during superovulation. During this time, the sperm’s survival in the upper genital tract must be at least two days. In some cases, the drug may also cause further enlargement of uterine fibroids. In such cases, a patient should consult her RE physician to determine the most appropriate course of action.

Patients who take clomiphene should know that the drug can decrease cervical mucus, which can make it difficult for sperm to travel through. This can result in failed attempts at conceiving. Luckily, there are ways to circumvent this problem. A woman may try to conceive through intrauterine insemination (IUI), a method that bypasses cervical mucus, which may improve her chances of conceiving.


There are a number of risks associated with taking Femara, a fertility drug. The drug blocks the enzyme that converts androgens into estrogens, thereby increasing the chances of conceiving. It is usually taken once daily for five days and is used to induce ovulation. Women taking Femara should plan to ovulate four to seven days after taking the final pill. After ovulation, a woman undergoes intrauterine insemination.

Women taking Femara should follow their healthcare provider’s instructions to prevent side effects. Usually, it should be taken once a day, but it may be taken every other day if liver problems are present. Femara may increase cholesterol levels, so patients will need to take extra medications to lower them.


Letrozole is a prescription fertility drug that can help women conceive. It works by blocking androgens from converting into estrogen, which stimulates the pituitary gland to produce follicle-stimulating hormone (FSH). This hormone triggers the ovaries to release an egg. Letrozole is often prescribed along with IVF. It helps women ovulate and regulate their menstrual cycle.

Letrozole is also used to treat breast cancer. It belongs to a class of drugs known as aromatase inhibitors, which block the production of estrogen in the body. In addition, letrozole can promote ovulation by increasing the amount of FSH and LH in a woman’s ovaries. The increased levels of these hormones can trigger ovulation in an anovulatory woman and increase the number of eggs in a woman who already ovulates.


There is a concern about multiples – the risk of multiple births is higher than that of single births. Women who are pregnant with multiples are at higher risk of premature delivery, low birth weight, and developmental problems. Oral fertility drugs can be helpful for women with ovulation problems, but they can also increase the chances of multiples. The risk of multiples is largely dependent on the age of the women and the cause of the infertility problem. If used appropriately, oral fertility drugs can increase the chance of pregnancy by as much as 10% and 20 percent when used in conjunction with artificial insemination.

The March of Dimes has advocated for more research on the topic and for more leadership from professional societies to develop and implement best practices in the treatment of women who are taking fertility drugs. The organization recommends counseling women taking fertility drugs and monitoring them closely.