Which Fertility Drugs Cause Multiples?

If you’re considering using fertility drugs, you might be wondering which of the medications may increase your chances of having multiples. This article will discuss Femara, Letrozole, and Clomiphene, as well as Injectable gonadotropins. Find out how to prevent multiple pregnancies by ensuring that your doctor is using the best practices for treating fertility drugs. If you’re considering using one of these drugs, ask your doctor what other steps you can take to prevent multiple pregnancies.

Letrozole and Metformin

Do Letrozole and Metformin cause several pregnancies? Some women may be surprised to learn that both drugs can cause multiples. Studies show that metformin and letrozole use can increase the risk of multiples. Combined use of these two drugs may improve the outcome. This combination is more effective for overweight women who have higher androgen levels and more severe anovulatory state. Both drugs may contribute to a more resistant hypothalamic pituitary ovarian axis. More research is needed to determine whether this is the case.


In the past, women who suffered from ovulatory dysfunction, such as irregular periods, sometimes had no menstrual periods for months. These women usually had Polycystic Ovarian Syndrome (PCOS). Because of its simplicity and relatively low risk of multiples, it was often prescribed for this purpose. However, Letrozole has now replaced Clomiphene as the first-line drug for PCOS and has also been shown to increase the live birth rate.


While there is no conclusive proof that Femara causes multiples, it does have a positive effect on ovulation. If taken correctly, a woman can conceive naturally on day 3 or day five of her menstrual cycle. Femara causes the egg to mature at a higher rate than normal, promoting superovulation. This hormone increases the chances of pregnancy by inhibiting the enzyme aromatase and enhancing the production of FSH, a hormone necessary to ovulate.

Injectable gonadotropins

The biggest risk associated with the use of injectable gonadotropins is the chance of conceiving multiples. It is estimated that as many as 20% of women who use gonadotropins will conceive multiples. These pregnancies are almost always twins. It is possible to reduce the chances of carrying multiples with careful monitoring. A doctor may cancel a treatment cycle if more than three follicles mature, or the levels of estradiol are very high. Studies have shown that as few as 5% of women who take gonadotropins experience multiple pregnancies, using a low dosage and gradual increase in dose, can reduce the risks of having multiples.


Infertility is a common problem among couples. Letrozole and other fertility drugs may help you conceive by increasing ovulation. Both letrozole and Femara are approved by the FDA for treating Polycystic Ovarian Syndrome, and fertility doctors may use these drugs to increase ovulation and increase a woman’s chances of becoming pregnant. Both drugs work by increasing the release of an egg, and both drugs are well tolerated.


If you are trying to conceive, you may be wondering if progesterone and fertility drugs can cause multiples. Both progesterone and fertility drugs are used to induce or sustain early pregnancy. Progesterone is the female hormone produced by the corpus luteum, a structure formed by the ovarian follicle after the egg is released. If you are trying to conceive, progesterone is essential for preparing the lining of the uterus for implantation. In case of failure to conceive, the progesterone production stops, but if pregnancy is achieved, the progesterone level continues to rise. Progesterone can also cause multiples when used in combination with other fertility drugs.